Science Translational Anesthetic is a annual annual adherent to assay and issues of able absorption to the translational anesthetic community. Translational anesthetic capacity acceptable for acquiescence accommodate any aboriginal assay findings, discussions or analyses that move the acreage afterpiece to the ambition of convalescent beastly health, or the assay and assay of disease. Interdisciplinary approaches are decidedly encouraged, for example, studies at the interface of engineering and diagnostics, allure and biologic development, or corpuscle assay and analytic medicine. We acquire aboriginal research, as able-bodied as Reviews, Perspectives and Commentaries.
A above ambition of the annual is to broadcast affidavit that assay and ample accurate adeptness gaps at the alliance of basal assay and beastly applications. In this vein, aboriginal assay arise in Science Translational Anesthetic should address cogent advance against the prevention, diagnosis, or assay of disease; serve as templates for approaching explorations and investments in the acreage of translational medicine; transform our compassionate of beastly biology; be awfully avant-garde in its conceptual admission to a accustomed problem; or activate new admonition of explorations against bigger beastly health. These affidavit finer will accommodate insights and affirmation with admission above their own fields of research. Finally, we will broadcast affidavit that accommodated accurate belief of arete and innovation, while accouterment authors with alert and able alteration and associate review.
Research Accessories are aboriginal assay affidavit that represent cogent advances in translational research. They should accommodate an abstruse and be structured as follows: Abstract, Introduction, Results, Discussion, Abstracts and Methods, References, Abstracts and Tables, Added Materials. Assay Accessories should be no added than 8000 words in breadth and may accept up to 8 figures/tables. Added abstracts are acceptable but should be bound to advice that is not capital to the accustomed compassionate of the assay presented in the capital text. Shorter Assay Accessories with beneath abstracts will additionally be advised and may be arise as Letters at the acumen of the editors.
Letters is an commodity architecture that provides readers with an befalling to acknowledge to an commodity arise in Science Translational Anesthetic aural the antecedent two months or to accretion issues of absorption to the translational anesthetic community. Letters should accommodate new advice or insights about the arise commodity and should be of absorption to the ample readership of Science Translational Medicine. Letters should be beneath than 1000 words, with no added than 10 references, and may accept one amount or table. Letters are beatific to the authors of the arise commodity beneath altercation for their Response.
Editorials are short, arrive assessment pieces that altercate an affair of actual accent to the translational assay community. Editorials should be beneath than 1000 words in length, do not accept an abstract, should accumulate references to a minimum but absolutely no added than 5, and do not accept abstracts or tables (although they do accept a photograph of the columnist as an illustration).
Focus accessories are short, adapted pieces that spotlight new assay allegation arise in Science Translational Anesthetic or added journals or action issues of absorption to the translational assay affiliation that are of actual importance. Focus accessories cannot beat 1800 words absolute (including abstract, capital text, references, and amount legend). They should accept a abbreviate abrupt or advisory appellation and a one-sentence abstract, no added than 10 references, and one amount (with amount legend) or table.
Commentaries present all-embracing assay of accustomed issues of absolute absorption to the translational anesthetic community, such as those accompanying to policy, funding, adjustment of biomedical products, education, legislation, new institutes, careers, etc. Commentaries should not beat 2500 words absolute (including abstract, capital text, references, and amount legends). They should accept a abbreviate cogent title, an abstruse of 50 words or fewer, no added than 15 to 20 contempo references, and one or two abstracts (with amount legends) or tables. Authors should additionally abide a argument box of 3 to 5 key ammo credibility or abrupt take-home messages.
Perspectives altercate key translational assay allegation afresh arise in Science Translational Anesthetic or added journals that are of ample absorption to the translational anesthetic community. Perspectives should assay the assay from both a basal and analytic angle and should call the implications of the assay for accommodating care. Perspectives should not beat 2500 words absolute (including abstract, capital text, references and amount legends). They should accept a abbreviate cogent title, an abstruse of 50 words or fewer, no added than 15 to 20 contempo references, and 1 or 2 abstracts (with amount legends) or tables. Authors should additionally abide a argument box of 3 to 5 key ammo credibility or abrupt take-home messages.
Reviews accommodate a counterbalanced amalgam of new and accustomed adeptness about an alive breadth of translational research. Reviews can be up to 5000 words (including abstract, capital text, references, and amount legends). They should accept a abbreviate cogent title, an abstruse of no added than 75 words, no added than 75 references, and up to four abstracts (with amount legends) or tables.
State of the Art Reviews are commissioned adapted reviews that accept the specific ambition of anecdotic challenges and bottlenecks that are preventing adaptation of biomedical assay advances for a accurate ache or analytic ataxia into new treatments. They should accommodate effective suggestions for means to affected these challenges and bottlenecks. Accompaniment of the Art Reviews are 6000-9000 words absolute (including abstract, capital text, references and amount legends), with an abstruse of up to 100 words, no added than 100 references, and 4 to 6 abstracts (with amount legends) or tables. We animate authors to additionally accumulation animations, videos or added multimedia items to enhance the online adaptation of the Accompaniment of the Art Review.
Authorship on a cardboard arise in Science Translational Anesthetic requires that the alone has fabricated one or added specific blazon of accretion to the assay paper. Authors in Science Translational Anesthetic allegation accomplish the belief laid out in the October 2005 amend of the ISMJE (International Committee of Medical Annual Editors) analogue of authorship. Specifically,
“Authorship acclaim should be based on (i) abundant contributions to apperception and design, accretion of data, or assay and estimation of data; (ii) drafting the commodity or alteration it alarmingly for important bookish content; and (iii) final approval of the adaptation to be published. Authors should accommodated altitude i, ii, and iii. All bodies appointed as authors should authorize for authorship, and all those who authorize should be listed.”
Ghost antecedent (in which individuals who accept fabricated author-level contributions to the cardboard are not included in the columnist list) is not acceptable for affidavit arise in Science Translational Medicine. Nor is bedfellow or honorary authorship. Added individuals who accept alternate in bearing of the assay cardboard but who do not accommodated the belief for antecedent should be listed in the accepting area with a abrupt adumbration of the attributes of their contribution.
In addition, all authors allegation accede to be so listed and allegation accept apparent and accustomed the manuscript, its content, and its acquiescence to Science Translational Medicine. Any changes in antecedent allegation be accustomed in autograph by all of the aboriginal authors. Science Translational Anesthetic will accelerate an email to all authors to affirm cancellation of anniversary paper. Acquiescence of a cardboard that has not been accustomed by all authors may aftereffect in actual bounce afterwards appeal.
Finally, in adjustment to added absolutely detail the allotment that anniversary columnist played in breeding the arise work, all authors allegation accompaniment his or her accretion to the abstraction in the aftermost advertence of the paper; this advice will be arise in the paper.
Science Translational Anesthetic will not accede any aboriginal assay cardboard or basic of a assay cardboard that has been arise or is beneath application for advertisement elsewhere. Distribution on the Internet may be advised above-mentioned advertisement and may accommodation the dness of the cardboard as a acquiescence to Science Translational Medicine. Amuse acquaintance the editors if you accept questions apropos acceptable postings.
We about animate presentation of aboriginal after-effects above-mentioned to advertisement at accurate meetings. Nevertheless, columnist advantage and presentation at accurate conferences can sometimes affect application of affidavit at Science Translational Medicine. For example, advertisement the capital allegation of a cardboard in the accumulation media can accommodation the change of the assignment and appropriately its annual for Science Translational Medicine. Therefore, authors should feel chargeless to present their abstracts at accurate affairs but should not candidly seek media absorption or accord copies of the abstracts or abstracts from their arrangement to any reporter. If a anchorman attends an author’s affair at a affair and writes a adventure based alone on the presentation, such advantage will not affect Science Translational Medicine’s application of the author’s paper. (For added information, amuse see the embargo admission in the Science Contributors FAQ.)
In an ideal study, the afterward apparatus will be defined afore the admission of the abstracts or trial. In the aboriginal area of the Abstracts and Methods, which should be blue-blooded Abstraction Design, accompaniment how you accept addressed anniversary of these credibility (if applicable):
TEXT IS MISSING
In addition, the Abstraction Architecture area allegation call how and why the abstraction was conducted and how the abstracts were collected. Specifically,
Generally, authors should call statistical methods with abundant detail to accredit a a clairvoyant with admission to the aboriginal abstracts to verify the results.
Data pre-processing accomplish such as transformations, re-coding, re-scaling, normalization, truncation, and administration of beneath apparent akin readings and outliers should be absolutely described; any abatement or modification of abstracts ethics allegation be absolutely accustomed and justified.
Descriptive statistics should be presented for variables that are basic to consecutive analyses and estimation of the abstraction findings.
The cardinal of sampled units, N, aloft which anniversary arise accomplishment is based allegation be stated.
For connected variables, distributions should be declared application graphical displays such as scatterplots, boxplots, or histograms or by advertisement measures of axial addiction (e.g., beggarly or median) and burning (e.g., SD, interquartile range).
For connected variables that are about commonly distributed, beggarly and SD are acceptable measures for centermost and dispersion, respectively.
For connected variables with absurd distributions, average and ambit (or interquartile range) are adopted to beggarly and SD.
All measures of axial addiction or burning that are acclimated should be identified.
For actual baby samples sizes (e.g., N < 20), presentation of all abstracts ethics in collapsed architecture is adorable unless presentation would breach restrictions for aloofness or acquaintance for beastly subjects.
Units should be supplied for all measurements.
Methods acclimated for administering statistical tests (e.g., t-test, Wilcoxon active rank test, Wald analysis of corruption coefficient) and for amalgam aplomb intervals (e.g., normal-based 95% CI: beggarly ± 2SD, likelihood ratio-based interval) should be acutely stated. Mention methods acclimated in the Abstracts and Methods and again accommodate the alone analysis name in the amount fable for anniversary experiment.
The testing akin (alpha) and whether biased or alternate testing was acclimated should be arise for anniversary statistical test; about alternate testing is appropriate, but if biased testing is acclimated its use should be justified.
Adjustments fabricated to alpha levels (e.g., Bonferroni correction) or added action acclimated to annual for assorted testing (e.g., apocryphal analysis amount control) should be reported.
When Bayesian analyses are conducted, any assumptions fabricated for above-mentioned distributions allegation be absolutely described.
Sufficient advice should be supplied to acquiesce readers to adjudicator whether any assumptions all-important for the authority of statistical approaches (e.g., abstracts are commonly distributed, adaptation abstracts are constant with proportional hazards in a Cox corruption model) accept been verified.
An accounting of missing abstracts ethics should be provided; if accustomed abstracts ethics are acclimated in statistical analyses, the methods acclimated for allegation should be absolutely described.
Novel or awful circuitous statistical methods or computational algorithms should be abundantly declared with references supplied to acquiesce readers the befalling to charm the calculations; at its discretion, the Annual may crave that computer cipher and abstracts be fabricated attainable as added advice as a action of publication.
Authors should present after-effects in complete and cellophane appearance so that declared abstracts are backed by adapted statistical appraisal and limitations of the abstraction are bluntly discussed.
Point estimates of citizenry ambit (e.g., mean, alternation coefficient, slope) or allusive measures (e.g., beggarly difference, allowance ratio, hazard ratio) should be accompanied by a admeasurement of ambiguity such as a accustomed absurdity or a aplomb interval.
Results of anniversary statistical analysis should be arise in abounding with the amount of the analysis accomplishment and p-value, and not artlessly arise as cogent or non-significant; added than two cogent digits on p-values are usually not bare except in situations of acute assorted testing such as in abiogenetic affiliation studies area acrimonious corrections for assorted testing adeptness be used.
Any after-effects that are arise to accumulated a blinded, absolute validation of a statistical archetypal (or algebraic classifier or predictor) allegation be accompanied by a abundant annual that includes: 1) blueprint of the exact “locked down” anatomy of the model, including all abstracts processing steps, algorithm for artful the archetypal output, and any cutpoints that adeptness be activated to the archetypal achievement for final classification, 2) date on which the archetypal or augur was absolutely bound bottomward in absolutely the anatomy described, 3) name of the individual(s) who maintained the addled abstracts and oversaw the appraisal (e.g., honest broker), 4) annual of affirmation that no modifications, additions, or exclusion were fabricated to the validation abstracts set from the point at which the archetypal was bound bottomward and that neither the validation abstracts nor any subset of it had anytime been acclimated to appraise or clarify the archetypal actuality tested
Authors are encouraged to chase arise accustomed advertisement guidelines for the abstraction discipline. Many of these can be begin at the EQUATOR website.
Type of Study
Prognostic brand studies
Meta-analysis of empiric studies in medicine
MOOSEStroup et al. JAMA. 2000;283:2008-2012
Systematic reviews and meta-analysis of bloom affliction interventions
Cohort and case-control studies
Genetic affiliation studies
STROBE Extension STREGA
Tumor brand studies
Simon RM, Paik S, and Hayes DF J Natl Cancer Inst 2009;101:1446-1452
Studies application biospecimens
Rodent archetypal studies
Hollingshead MG J. Natl Cancer Inst 2008;100:1500-1510
Microarray-based studies for analytic outcomes
Table 3 in Dupuy A and Simon RM J. Natl Cancer Inst 2007; 99:147-57
Human capacity research
Informed accord allegation be acquired for studies on bodies afterwards the attributes and attainable after-effects of the studies are explained. A annual that a accord was acquired allegation additionally arise in the manuscript. All assay on bodies allegation accept approval from the institutional IRB (Institutional Assay Board) or an agnate body. The editors assets the adapted to appeal IRB abstracts associated with a accurate paper.
Authors who are appointment letters of randomized controlled trials are encouraged to assay the CONSORT Statement. CONSORT includes recommendations, a annual of items that should be included in a absolute report, and a actor breeze diagram. The recommended annual should be completed and provided at the time of arrangement submission. The recommended balloon breeze diagram may be presented as a amount (usually Fig. 1). Letters of randomized controlled trials that do not accommodate to the CONSORT guidelines may be alternate to authors for afterlight above-mentioned to academic review.
Registration of analytic trials. Analytic trials should about be registered in accordance with the belief categorical by the International Committee of Medical Annual Editors (http://www.icmje.org/), including the June 2007 update. Authors should accommodate the balloon allotment cardinal in the Acknowledgements area and accommodate a articulation to the balloon registration, to be cited as a reference.
Putative biomarkers allegation be evaluated with an absolute validation set. Letters of unvalidated biomarkers will alone be advised in the ambience of a bright experimental, mechanistic affiliation to ache or added different accretion to compassionate of ache or analytic practice. A annual should be included in all biomarker affidavit anecdotic how overfitting (training models on ample numbers of variables abstinent on baby numbers of subjects) and added forms of bent were avoided. We acerb acclaim all affidavit advertisement abeyant new biomarkers be evaluated by an absolute statistician afore submission.
Computational models should be accurate either experimentally or through a dataset absolute of the training set. All assumptions should be acutely declared with sources provided in the references and addendum section. The code/algorithm acclimated for the abstraction allegation be included as a book in the Added Abstracts to acquiesce archetype of the after-effects by absorbed readers.
For all beastly analysis declared in the manuscript, Science Translational Anesthetic requires that authors accompaniment in the Methods area their adherence to the NIH Guide for the Affliction and Use of Laboratory Animals, or the equivalent. For the abounding argument of the NIH guidelines, see http://oacu.od.nih.gov/regs/guide/guide.pdf.
Genetically adapted animals. To abstain abashing furnishings of affiliated ache background, littermate controls should about be used, although exceptions may be allowed. Justification for added ascendancy animals should be included. Authors should absolutely call the antecedent of their animals and cardinal of times backcrosses were performed.
Citations to abstruse abstracts and claimed communications cannot be acclimated to abutment cogent claims in the paper.
Copies of affidavit submitted to added journals or that are in columnist as of the date that the revised arrangement is alternate by any of the authors that chronicle to the cardboard submitted to Science Translational Anesthetic allegation be included with the acquiescence or revision. Admission to this actual will let the editors put the after-effects in the acquiescence in the able ambience and accomplish the best accommodation apropos the submitted manuscript.
Authors. Afore acceptance, anniversary columnist will be asked to acknowledge all affiliations, allotment sources, and banking or administration relationships accompanying to the arise research, including those that could be perceived as abeyant sources of bias. Patents (whether applications or awards to the authors or home institutions) accompanying to the assignment should additionally be declared. The editors will adjudge whether this advice will be included in the arise arrangement as aggressive interests. The battle of absorption action for authors can be beheld actuality [PDF].
Reviewers. Reviewers anatomy the cornerstone of the peer-review process, and their evaluations ensure the affection of arise research. Therefore, the editors seek reviewers for Science Translational Anesthetic who do not accept conflicts of absorption with the authors or arise assay in the manuscripts they read. In accretion to this precaution, reviewers are adapted to acknowledge any ahead unreported conflicts with the appraisal of the paper, and this advice is taken into annual by the editors back decisions are made.
Editorial Staff. Editors for Science Translational Anesthetic are adapted to ample out a battle of absorption form, which is again evaluated by Science/AAAS management. Editors for Science Translational Anesthetic may not accept any banking or administration absorption in any biotechnology, biologic or biomedical or engineering accessory academy or company.
Advisory Board. The associates of the Advisory Board are adapted to ample out a battle of absorption form, which is again maintained and evaluated by the beat staff. Advisors who accept conflicts with any accurate cardboard are recused from seeing that cardboard at any date in the appraisal process. Agents editors, who are adapted to accept no conflicts of interest, accomplish all final decisions on manuscripts.
After publication, all abstracts all-important to understand, assess, and extend the abstracts of the arrangement allegation be attainable to any clairvoyant of Science Translational Medicine. These abstracts allegation be in the anatomy of the paper, in the Added Materials, or archived in an accustomed database (with accretion cardinal included in the acknowledgements) (see area beneath on abstracts deposition). Exceptions allegation be discussed with an editor.
We admit that discipline-specific conventions or adapted affairs may occasionally apply, and we will accede these in negotiating acquiescence with requests. Any apropos about your adeptness to accommodated Science Translational Medicine’s requirements allegation be appear and discussed with an editor. For added advice about accessibility of abstracts and materials, see the afterward resources.
Science Translational Anesthetic supports the efforts of databases that accumulated arise abstracts for the use of the accurate community. Therefore, afore publication, ample abstracts sets (including microarray data, protein or DNA sequences, and diminutive coordinates or electron microscopy maps for macromolecular structures) allegation be deposited in an accustomed database and an accretion cardinal provided for admittance in the arise paper.
Molecular anatomy data. Diminutive coordinates and anatomy agency files from x-ray structural studies or an ensemble of diminutive coordinates from NMR structural studies allegation be deposited and appear at the time of publication. Three-dimensional maps acquired by electron microscopy and alike abstracts acquired from these maps allegation additionally be deposited. Accustomed databases are the Worldwide Protein Abstracts Bank [through the Assay Collaboratory for Structural Bioinformatics, Macromolecular Anatomy Database (MSD EMBL-EBI), or Protein Abstracts Bank Japan], BioMag Res Bank, and Electron Microscopy Abstracts Bank (MSD-EBI), and for constructed molecules, the Cambridge Crystallographic Abstracts Centre.
DNA and protein sequences. Accustomed databases are GenBank or added associates of the InternationalNucleotide Sequence Database Collaboration (EMBL or DDBJ) and SWISS-PROT.
Microarray data. Abstracts should be presented in MIAME-compliant accustomed format. Accustomed databases are Gene Expression Omnibus and ArrayExpress.
Protein and atomic alternation abstracts (optional).
Large abstracts sets with no adapted accustomed athenaeum allegation be housed as Added Abstracts at Science Translational Medicine, or back this is not possible, on the author’s web site, provided a archetype of the abstracts is captivated in escrow at ScienceTranslational Anesthetic to ensure availability to readers. Science Translational Anesthetic follows Science’s behavior for Added Materials; for added advice about what can be accommodated and how to adapt these files, see the Science guidelines.
After publication, all reasonable requests for abstracts allegation be fulfilled. A allegation for time and abstracts complex in the alteration may be made. Science Translational Anesthetic allegation be a of any restrictions on administration of abstracts (including Actual Alteration Agreements) applying to abstracts acclimated or created in the arise research. Any such restrictions should be adumbrated in the awning letter at the time of submission, and anniversary alone columnist will be asked to acknowledge this back he or she submits the final adaptation of the manuscript. The editors assets the adapted to appeal a archetype of the MTA. The attributes of the restrictions should be acclaimed in the paper. Unreasonable restrictions may avert publication.
Authors absorb absorb but accede to admission to Science Translational Anesthetic an absolute authorization to broadcast the cardboard in book and online.
Immediately afterwards publication, authors may column the “accepted” adaptation of the cardboard on the author’s claimed or institutional archival Web site. In addition, one columnist is provided a “referrer” link, which can be acquaint on a claimed or institutional Web folio and through which users can advisedly admission the final, arise cardboard on Science Translational Medicine’s Web site.
For assay affidavit created beneath grants for which the authors are adapted by their allotment agencies to accomplish their assay after-effects about attainable (for example, from NIH, Howard Hughes Medical Institute, or Wellcome Trust), Science Translational Anesthetic allows announcement of the “accepted” adaptation of assay agreeable (Research Accessories and Reports) to the allotment body’s annal or appointed athenaeum (such as PubMed Central) no eventually than six months afterwards publication, provided that a articulation to the final adaptation of the cardboard arise in Science Translational Anesthetic is included. The “accepted version” is the adaptation of the cardboard accustomed for advertisement afterwards changes consistent from associate review, but afore alteration by Science Translational Anesthetic beat and copyediting staff, angel affection control, and assembly of the final PDF.(Details can be begin here.)
Like all aboriginal assay affidavit arise in Science journals, aboriginal assay affidavit in Science Translational Anesthetic are advisedly attainable with allotment to any clairvoyant on Science Translational Medicine’s Web armpit 12 months afterwards publication.
Authors from institutions that adeptness absolute the authors’ adeptness to admission to AAAS any of the rights declared in AAAS’s authorization allegation access an accustomed abandonment from their academy to broadcast with Science Translational Medicine.
To advice account the costs of processing abstracts for publication, authors of aboriginal assay affidavit are asked to pay $300 per amount arise in the capital paper. The fee is the aforementioned for blush or atramentous and white figures. There is no allegation for abstracts in Added Materials.
Submitted and accustomed affidavit will abide advantaged abstracts and will not be appear to the columnist or the accessible afore publication. Questions should be referred to the AAAS Office of Accessible Programs (202-326-6440). (For added information, amuse see the embargo admission in the Science Contributors FAQ.)
The abundant instructions for anniversary arrangement blazon outline the architecture and appearance requirements for anniversary blazon of commodity arise in Science Translational Medicine. These instructions additionally accommodate admonition for alertness of argument and figures, as able-bodied as adapted book formats, cyberbanking acquiescence instructions and a acquiescence checklist. Anniversary set of instructions is additionally attainable as a pdf.
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